ECHO aimed at building a common knowledge infrastructure based on existing datasets, which ultimately allowed international healthcare performance comparisons.
Conceived as a pilot study, ECHO set about the task of bringing together patient-level data from Denmark, England, Portugal, Slovenia and Spain, and contextual information -demographic, socioeconomic, and healthcare supply data.
This knowledge infrastructure allows evaluating more than 40 performance indicators, carefully developed to avoid inappropriate cross-country comparisons.

Investigate the relationships between diet, nutritional status, lifestyle and environmental factors, and the incidence of cancer and other chronic diseases

To develop and operate a routine public health mortality monitoring system aimed at detecting and measuring, on a real-time basis, excess number of deaths related to influenza and other possible public health threats across European countries.

Surveillance system that provides information on non-fatal unintentional injuries such as home injuries, sports and leisure, workplace and road injuries; in addition to intentional injuries resulting from violence and self-harm.

The Survey of Health, Ageing and Retirement in Europe (SHARE) is a research infrastructure for studying the effects of health, social, economic and environmental policies over the life-course of European citizens and beyond. From 2004 until today, 530,000 in-depth interviews with 140,000 people aged 50 or older from 28 European countries and Israel have been conducted.

TEPHINET aims to improve Field Epidemiology Training Programs, thereby facilitating their integration into every country in the world and ensuring sustainability and long-term funding.

The objective of the Euro-Peristat Network is to establish a high quality, innovative, internationally recognized and sustainable European perinatal information system. This system's goal is to produce data and analysis on a regular basis for use by national, European and international stakeholders who make decisions about the health and health care of pregnant women and newborns.

What are the most relevant diseases in a country? Which risk factors are the strongest contributors to disease and death? How is the impact of different diseases evolving over time, and how does it compare between countries and within subnational units? As the need for prioritising the use of available resources constantly increases, a timely, sound and comprehensive answer to these fundamental questions is more than ever needed to inform public health decision making.