This e-learning course, developed in November 2021, during the COVID-19 pandemic, aims at increasing understanding of the drivers of vaccine acceptance and design targeted strategies to increase vaccine uptake. 
Objectives: After completing this course, you will be able to: Describe the 5C model and advocate for its use in diagnosing barriers to vaccine acceptance and uptake, and in designing adapted strategies; Describe why diagnosing the barriers to vaccine acceptance and uptake is essential, and recognise the data collection tools that may be used; Understand the need to evaluate behaviour change interventions, and describe how this may be done considering the complexity of causality in behavioural interventions.