Recent advancements in health-related artificial intelligence (AI) have ignited discussions concerning the potential encroachment on personal privacy and the impact on public health. To delve into these issues and other factors influencing the current and future landscape of health systems in the European Region, WHO/Europe is hosting the second WHO Symposium on the Future of Digital Health Systems on September 5-6. Over the two days, participants will engage in discussions covering a range of topics, including the potential of digital health in combating noncommunicable diseases, digital solutions for pandemic preparedness, One Health considerations, using digital tools in communicable disease prevention, the role of AI and precision medicine in personalized care, telehealth's transformative potential, data-driven decision-making, and the application of emerging technologies in mental health. The event will also mark the launch of a new flagship regional report titled "Leveraging and scaling up digital transformation for better health and resilience in the European Region," presenting fresh data from all 53 Member States.