PHIRI is a roll-out of the research infrastructure on population health information to facilitate and generate the best available evidence for research on health and well-being of populations as impacted by COVID-19. PHIRI will allow for better coordinated European efforts across national and European stakeholders to generate the best COVID-19 population health knowledge. In doing so, PHIRI will lay the foundation to build a Distributed Infrastructure on Population Health (DIPoH) to be used to overcome future crisis and ensuring the sustainability of the project. The intent is to support research across Europe through the identification, access, assessment and reuse of population health and non-health data to underpin public health policy decisions. This will be achieved through a close collaboration with 41 partners across 30 countries over a period of 36 months starting in November 2020. The project is divided in 9 ambitious work packages with three transversal topics. PHIRI builds on the achievements of the BRIDGE Health and the Joint Action on Health Information (InfAct) projects.